Abstract

ROLE OF ALLIUM HOOKERI AGAINST HIGH BLOOD PRESSURE AND HYPERLIPIDAEMIA CONDITIONS IN WISTER RATS

Khumanthem Deepak Singha* and Dipak Chetiab

ABSTRACT

In an effort to search for complementary and alternative remedies, this study was designed to investigate the antihypertensive and hyperlipidaemia effect of Allium hookeri (AH) leaf extract. Evaluation of antihypertensive and hypolipidemic activity of Allium hookeri leaves were carried out in Wister rats. Hypertension was induced by 2-Kidney-1-Clip (2K1C) surgical model and initial blood pressure was measured after 7 days. After treatment of 14 days consecutively, final reading was measured. Hypolipidemic activity was studied after inducing by Triton WR 1339 for a period of 30 days. Lipid profiles (Cholesterol, Triglycerides, Low Density Lipoprotein and High Density Lipoprotein) were estimated on 0, 10, 20 and 30 days. In vivo antioxidant status and histopathology studies of the liver were studied. A significant (p<0.01) reduction in blood pressure was found in the hypertensive animals after 14 days treatment of AH. After 30 days of
treatment, the total cholesterol, triglycerides, low density lipoprotein decreased and high density lipoprotein increased significantly (p<0.01). AH reduced the lipid levels and improved the level of superoxide dismutase, glutathione reductase and catalase in liver. Histopathological studies of liver in hyperlipidaemia and treated groups substantiate the cytoprotective action of the extract. Present findings demonstrated the significant antihypertensive and hypolipidemic activity of the Allium hookeri extract which consist of important bioactive compounds to warrant their use in complementary and alternative treatment against hypertension and obesity. Thus, the Allium hookeri extract could be used as a readily accessible source of natural antioxidants, and may be used in the pharmaceutical industry and for food supplements production.

Keywords: 2K1C, blood pressure, heart rate, lipid profiles, Allium hookeri.