Abstract

ANALYSIS OF DIBENZYLIDENE DERIVATIVES (D3 & D4) ON PAIN THRESHOLD IN EXPERIMENTAL MICE MODEL

Joffa PPK*, Erigbali P. P., Kiridi E. G., Pughikumo D. T., Erigbali V. T. and
Lelei S.

ABSTRACT

Pain management is a critical aspect of healthcare, and the search for effective analgesics with fewer side effects remains a significant challenge. This research aimed to analyze the effect that two derivatives (D3 & D4) of dibenzylidene pain threshold, using mice model. In this study, mice were randomly assigned to different treatment groups - control, various doses of D3 & D4 then tramadol (as standard). Pain was induced in the mice using thermal stimuli, and pain threshold assessed by measuring the latency period for paw licking or jumping. The results showed that administration of D3 & D4 in graded quantity slightly increased threshold of pain than control treatment in the mice, but with no statistical significance (P<0.0001), also no dose-dependence. From these findings, we can infer that D3 and D4 in
isolation may not have significantly increased pain threshold at (P<0.0001), but this does not foreclose future investigations of their analgesic potential as combination therapeutic regimens or at other doses. Thus, further investigations with these derivatives will not be out of place.

Keywords: Pain, Dibenzylidene, Derivatives, Tramadol, Threshold.