Abstract

RATING OF MULTI-DRUG RESISTANT PULMONARY TUBERCULOSIS IN NEW CASES, ELDAMAZEN TUBERCULOSIS CENTER, BLUE NILE STATE, SUDAN (2022)

Ammar Mohammed, Sid M. A., Salah E. I.*, Hassan Mohamed Eissa and Abdelrahim M. Abdelrazig

ABSTRACT

Objective: The study aimed to detect Ratio of Multi-drug Resistant Pulmonary Tuberculosis in New Cases, ELdamazen Tuberculosis Center, Blue Nile State, Sudan (2022). Material and Methods: Early morning sputum samples were obtained and subjected for Zn staining Mycobacterium tuberculosis DNA and rpoB gene detection. Density of tubercle bacilli by Zn stain recorded as; +1, +2 and +3 while GeneXpert technique used for Mycobacterium tuberculosis DNA and multi-drug resistance identification. Rsults: In the results, a total of 72 participants were enrolled, males were predominated with percentage of 65.3% (47 /72) while the age group from 21 to 40 years constituted 57% (41/72). Fourty one percent, 47%, 42% and 38.9% of study subjects were primary educated, smokers, alcoholic drinkers and had a history of tuberculosis contact respectively. Mycobacterium tuberculosis DNA as detected in all tested sputum (n=72) while Zn
stain gave false negative results in 19% (14/72). Multi-drug resistance tuberculosis was determined in 2.8% (2/72) of cases. and ZN stain is less sensitive than PCR. The reinforcement of health education, total Directly Observation Therapy programs coverage for all TB patients, and working on identifying determinants are highly recommended to and Consequently, the National TB program, should maximize efforts to combat TB and anti-TB drug resistance, and complete the ongoing national survey to more accurately ascertain the incidence of MDR-TB in Sudan. Besides increasing the number of treatment centers and the free provision of TB medicines.

Keywords: Tuberculosis(TB) and Multi-drug resistance tuberculosis (MDR-TB).