Abstract

THERAPEUTIC MONITORING OF CYCLOSPORINE-A IN IRAQI PATIENTS KIDNEY TRANSPLANTED

Hassan Mohamed Al-Temimi Mowafaq Mohammed Ghareeb, Ali Abdulmajid Dyab, Kawther Faris Al-Temimi*

ABSTRACT

Cyclosporine A (CSA) is selective immunosuppressant widely used in kidney transplant, this study was designed to monitor the drug plasma concentration and evaluation its safety and efficacy in Iraqi centre of Therapeutic drug monitoring. The blood samples were analyzed for the concentration of CSA by using AXSYM automated florescence polarization immunoanalyzer. Clinical parameters concerning CSA concentrations with its safety were measured for 60 patients receiving 5mg/Kg/day orally in two divided dose every 12hr after kidney transplant. The measured area under the concentration-time curve (AUC) describes total drug exposure during the entire dosing interval (0-12 hr).There are a significant elevation (P

Keywords: cyclosporine A, kidney transplant, clinical parameters, TDM.