Abstract

HERBAL NANOEMULGEL: A PROMISING APPROACH FOR PSORIASIS MANAGEMENT - A REVIEW

Sandhya Sharma*, Nayyar Parvez and Amarjeet Singh

ABSTRACT

Psoriasis is a skin autoimmune disease characterised by inflammation and proliferation. T-cell activation is the mechanism behind psoriasis, which is characterised by unique, peach-pink or dull-red, stiffened patches with silvery scales that cause recognisable skin lesions. In addition, it causes abnormal keratinization, and infiltration of inflammatory cells into the epidermis. The autoimmune disease psoriasis is a chronic, inflammatory condition that affects 2-3% of the global population. Topical treatment is the first line of defence against psoriasis. Since patients are less likely to adhere to long-term therapy while using the present formulation (ointment), which is greasy and irritates skin, there is a need for a more efficient way to distribute medications. The nanosized structure of nanoemulsion allows for more penetration and retention into the skin, which is beneficial in psoriasis because psoriatic skin is rough and covered in plaques. It can easily be turned into a gel, which prolongs drug administration, boosts patient compliance because it's non-greasy and non-sticky, and enhances skin hydration and medicine distribution into the skin. Herbal nanomedicines for psoriasis are utilised to deliver phytoconstituents with a reduced toxicity profile and an improved therapeutic profile. The antipsoriatic properties of phytoconstituents loaded nanomedicines have demonstrated great therapeutic potential in the treatment of psoriasis in recent years. The intention of the study is to review herbal nanomedicines with better efficacy for the management of psoriasis.

Keywords: Topical route, Herbal Drug, nano-emulgel, lipophillic drugs, bioavailability,