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SYNTHESIS, BIOLOGICAL EVALUATION OF SOME HETEROCYCLIC DERIVATIVES AS AN ANTIMICROBIAL AGENT
Sayali Dalvi* and Snehal Patil
ABSTRACT
Some new heterocyclic compounds containing benzimidazole and chalcone derivatives were prepared from various chalcones. The synthesized compounds have been characterized by TLC, IR, and 1H NMR spectroscopy methods. These compounds were screened for their antimicrobial activities. 2-aminomethyl benzimidazole fused with chalcone derivatives were synthesized by nucleophilic substitution reaction between 2-(chloromethyl)-1H-benzimidazole and N-3-((1H-benzo[d]imidazole-2-yl) methylamino)-3-phenylprop-1-enyl) phenol. First 2-(aminomethyl)-1H-benzimidazole was yielded by Phillip’s condensation of o-phenylenediamine with chloroacetic acid. Then these two moieties were fused by using nucleophilic substitution reaction to afford corresponding target compounds. The antibacterial activity of benzimidazole derivatives have been assessed with zone of Keywords: Benzimidazole, Chalcone derivatives, Antimicrobial activity. [Download Article] [Download Certifiate] |