Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF TRIBULUS TERRESTRIS EXTRACT CAPSULES DELIVERY SYSTEM AS AN ADVANCED PHYTOTHERAPY APPROACH FOR KIDNEY STONES

Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany

ABSTRACT

Urolithiasis is a common problem and affects a considerable number of people worldwide. Globally, 12% of population suffers from kidney stone at a stage of life. Kidney stones are the third most common urinary tract disorders after urinary tract infections and prostate pathology. Kidney stones may cause extreme pain and blockage of urine flow. They are usually treated with drugs that may cause a number of side effects. Medicinal herbs may be useful in treatment of kidney stones. Tribulus Terrestris is medicinal herb widely distributed in Yemen. It is medicinal herbs have been used in the treatment of kidney stones, diabetes, diuretic, antibacterial, liver disease, heart disease, anti-inflammatory, anti-tumor, anti-oxidant, anti-infertility, aphrodisiac activity, antiurolithiatic activity, anti-stress, hepatoprotective activity, analgesic, antispasmodic and anthelmintic. In the present study the Tribulus Terrestris extract was formulated and evaluated as capsules. It was concluded that among the all formulations of Tribulus Terrestris extract capsules the F5 was found to be as an optimized capsules according to drug release percentage 94% within 60minutes in buffer medium, so the F5 was the best formulation of Tribulus Terrestris extract capsules delivery system as an advanced phytotherapy approach for kidney stones.

Keywords: Tribulus Terrestris, Extract, Capsules, Kidney stones, lithotriptic, Phytotherapy.