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A RESEARCH OF DEVELOPMENTAL ANALYSIS OF HPLC METHOD IN MOXONIDINE HYDROCHLORIDE
M. Kalaichandar*, Aswini Sandu, S. Shanmugapriyanka, P. D. Gokulan, K. L. Senthil Kumar and K. Kirubakaran
ABSTRACT
This Scientific paper consists of the information of HPLC new method development and Validation as per ICH Guidelines. It also explains importance of HPLC method development and types of HPLC columns. In this paper new binger clearly understand how new method development carried out and what are the ICH guidelines regarding any new method development by HPLC. A simple, precise, specific sensitive and accurate high performance liquid chromatographic (HPLC) method was developed for the determination of Moxonidine in tablet dosage form. This method then applied on formulations as its application. It will help to budding students for new method development and it’s validation A simple, sensitive, precise and rapid high performance liquid chromatography (HPLC) method was developed and validated for simultaneous estimation of Moxonidine in bulk drug and tablet dosage forms. The separation was achieved by using Qualisil BDS C18 (25cm X 4mm, 5μm) as stationary phase and The developed HPLC method was then applied for the simultaneous estimation of Moxonidine in marketed tablet formulation. The % assay of Moxonidine by proposed method was obtained in the range of 99.0%-105 %respectively, which was well within the acceptance criteria limit of 90-110% indicating that the method can be applied for simultaneous determination of Moxonidine in marketed tablet formulation. Hence, the developed HPLC method results shows to be accurate, precise, linear, robust, rugged and specific. The proposed method is simple, accurate, cost effective, less time consuming and the analysis proved that the method is reproducible and efficient for the simultaneous estimation of Moxonidine as bulk drugs and combined dosage forms without any interference from the excipients. The developed method could be conveniently adopted for routine analysis in quality control laboratories. Keywords: Moxonidine, British Pharmacopoeia, Monograph, High performance liquid chromatographic (HPLC), Assay, Analytical Method Validation. [Download Article] [Download Certifiate] |