Abstract

A BRIEF REVIEW ON CHIRAL SEPARATION OF DRUGS

Avinash Kumar Singh, Anil Kumar Singh, Nagarajan Janaki Sankarachari Krishnan*, Jebisel Reba Paul Moses, Karthick Rajendran, Lokesh Raja Janarthanan and Meiyappan Varadharaj

ABSTRACT

Chiral separation is a technique used in the pharmaceutical sector to separate the isomers of racemic substances. It has significant implications across various fields, including pharmaceuticals, agrochemicals, and the development of advanced materials. Enantiomers can exhibit varying biological behaviors, and the resolution of one and multi-chiral center racemates is crucial. One enantiomer is active and other may not be. But sometime it gives undesirable action. Different ways the enantiomers can be isolated. Recent year’s chrial chromatography technique is used to separate the isomers. High-performance liquid chromatography (HPLC) is primarily used for enantiomer separation, with two distinct approaches: indirect and direct. However, there is a lack of research on separating all possible enantiomer forms of a compound, highlighting the need for further research in this area.

Keywords: Enantiomers can exhibit varying biological behaviors, and the resolution of one and multi-chiral center racemates is crucial.