Abstract

A REVIEW ON FLOATING GEL

Pinky Gupta*, Kamal Singh Rathore and Rakhi Verma

ABSTRACT

Drugs with a narrow absorption window in the gastrointestinal tract (GIT) face challenges in oral administration due to incomplete release and short residence time, leading to poor bioavailability. To address this, novel gastro retentive systems like floating systems, muco-adhesive, high-density, and expandable systems have been developed. These systems enable controlled drug delivery with prolonged gastric residence time. Liquid oral formulations are particularly susceptible to low bioavailability due to their rapid elimination from the stomach. This issue is tackled by formulating them as oral in situ gels, which overcome immediate release and short residence problems. In situ gel dosage forms are initially liquid but, upon contact with gastric contents, undergo gelation through various mechanisms, floating on
gastric contents and prolonging residence time while ensuring sustained release. This approach benefits both systemic and local drug effects and has been explored extensively by researchers across various drugs and polymers, as outlined in this review.

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