Abstract

A REVIEW ON CHALCONE SYNTHESIS AND ITS DERIVATIVE AS ANTIBACTERIAL AND CYTOTOXIC ACTIVITY

Sayali Dalvi* and Smita J. Pawar

ABSTRACT

Chalcones can be easily modified chemically and synthesised to produce a wide range of molecules with various structures. This review provides an update on the recent developments in the antibacterial and cytotoxic activity of natural and synthetic chalcones.Chalcones mainly consist of polyphenolic compounds whose colors vary from yellow to orange and contribute significantly to the pigmentation of the corolla of some plants. Chalcones, which are naturally found in fruits, spices, teas, and soy-based foods, have gotten a lot of attention owing to their intriguing and potentially beneficial properties. Moreover, these molecules are found in natural products as pheromones, plant allelochemicals, and insect hormones. Chalcones undergo many chemical reactions as well as being used to synthesizeheterocyclic compounds. It is possible to synthesize a wide range of chalcone derivatives by treating aromatic aldehydes with aryl ketones in the presence of an appropriate amount of condensing agents.They are constituted of open-chain flavonoids chemically, Chalcones are secondary metabolites of an edible or medicinal plant and are classified as part of the flavonoid family. Two aryl moieties are connected by an, -α-β-unsaturated carbonyl group to form chalcones, 1,3-diphenyl-2-propen-1-ones The structure of these compounds has a C=O-CH=CH keto ethylenic moiety. Aldehydes and ketones can be used as starting materials in a variety of methods to synthesize chalcone. This review focuses on the various methods used to synthesize chalcones' diverse biological properties, such as their antibacterial and cytotoxic properties.

Keywords: Chalcone synthesis, Antibacterial Activity and Cytotoxic activity.