Abstract

CHEMISTRY, SAR, AND BIOLOGICAL PROPERTIES OF SEMICARBAZIDE MOIETY: A CRITICAL REVIEW

*Pragati Kumari, Deepti Sachan and Jaswant Singh

ABSTRACT

Heteroatoms are a common fragment of many active pharmaceutical ingredients and excipients; from a significance perspective. The current review was based on the chemistry, SAR, and biological properties of semicarbazide moiety. A substitution of an oxygen atom with a sulfur atom in a semicarbazone results in the formation of a thiosemicarbazone. These thiosemicarbazones operate as chelating ligands and form complexes with metallic cations when they contact. The substance is a white solid that can be dissolved in water. It is derived from urea. the anticipated photochemical behavior of the phenyl azide group is a more crucial determinant than the IC50 of the photoprobe in achieving a successful photolabeling event. Chelating ligands such as semicarbazone and thiosemicarbazone have a tendency to create complexes with metallic cations. In conclusion, researchers have demonstrated that the semicarbazone moiety and its many derivatives possess potent pharmacological properties. Semicarbazide analogues have great potential in the synthesis of novel drugs for the treatment of various widespread diseases i.e., cancer, convulsion, hepatotoxicity, arthritis, pain and inflammation, oxidation, malaria and viral infection.

Keywords: Semicarbazide, heterocyclic compounds, biological properties, antioxidant, anti-cancer.