Abstract

FORMULATION AND EVALUATION OF GASTRO RETENTIVE MATRIX FLOATING TABLETS OF NIFIDIPINE

P. Glory Margaret* and Ashok Thulluru

ABSTRACT

A significant field of innovative drug delivery systems is the rate- controlled oral medication administration system. In order to overcome physiological challenges such brief stomach residence times and irregular gastric emptying times, recent scientific and technology research has focused on the creation of rate-controlled drug delivery devices. Floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bio adhesive systems, high-density systems, modified- shape systems, and other delayed gastric emptying devices are some of the methods being used to extend the GRT. Floating drug delivery systems are specifically engineered to extend the duration of gastric residence time following oral administration. This allows for precise control over drug release, which is particularly beneficial in attaining a regulated plasma level and enhancing bioavailability. Drug delivery devices that float are ones that stay in the stomach for extended periods of time. The study's primary goal was todevelop and assess nifedipine floating tablets. The polymer utilised was hydroxypropyl methyl cellulose (HPMC K100M). This work demonstrates that nifedipine GFDDS may be created with HPMC K100M as the matrix polymer, potentially increasing the medication's oral bioavailability.

Keywords: Drug delivery, Bioavailability, Floating tablets, Nifedipine.