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FORMULATION AND EVALUATION OF GASTRO RETENTIVE MATRIX FLOATING TABLETS OF NIFIDIPINE
P. Glory Margaret* and Ashok Thulluru
ABSTRACT
A significant field of innovative drug delivery systems is the rate- controlled oral medication administration system. In order to overcome physiological challenges such brief stomach residence times and irregular gastric emptying times, recent scientific and technology research has focused on the creation of rate-controlled drug delivery devices. Floating drug delivery systems (FDDS), swelling and expanding systems, polymeric bio adhesive systems, high-density systems, modified- shape systems, and other delayed gastric emptying devices are some of the methods being used to extend the GRT. Floating drug delivery systems are specifically engineered to extend the duration of gastric residence time following oral administration. This allows for precise control over drug release, which is particularly beneficial in attaining a regulated plasma level and enhancing bioavailability. Drug delivery devices that float are ones that stay in the stomach for extended periods of time. The study's primary goal was to Keywords: Drug delivery, Bioavailability, Floating tablets, Nifedipine. [Download Article] [Download Certifiate] |