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FORMULATION AND EVALUATION OF BI LAYER TABLETS OF IBUPROFEN AND FAMOTIDINE
Ranjit Goud.P*, Neeharika. M.S, Deepika HC, Sikanth CH, Tarika A, Manasa P
ABSTRACT
The main objective of this research work was to formulate and evaluate the bi layered tablets of ibuprofen and famotidine by using different polymers. Ibuprofen is an NSAID and famotidine is a H2 receptor antagonist. The tablets containing immediate releasing layer and sustained release layer. The ingredients used are microcrystalline cellulose pH 102, sodium starch glycol ate, cross carmellose, povidone for immediate releasing layer, HPMC K15m, K4m, E15cps, Carbomer 934p, and natural gums like guar gum, Xanthan gum for sustained drug release layer. The bilayered tablets were prepared by direct compression and wet granulation methods. All the excipients are tested for compatibility with drug, which revealed that there was no physical Keywords: Ibuprofen and famotidine, sodium starch glycolate, HPMC K15m, bilayered tablets formulation, immediate and sustained release, dissolution studies. [Download Article] [Download Certifiate] |