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PREPARATION AND EVALUATION OF FLOATING TABLETS OF MONTELUKAST SODIUM
Sandip V. Jadhav*, Manjunath G. Mukkane, Bhimashankar K. Bhui, Sakshi S. Hotkar, Satyajeet A. Gorave and Sujit A. Jamadar
ABSTRACT
The new formulation, which contains montelukast sodium for the management of persistent asthma, was created by creating floating tablets using various combinations of natural and synthetic polymers. The seven formulations of floating tablets of montelukast sodium are created using hydroxyl propyl methyl cellulose, guar gum and xanthan gum, where sodium bicarbonate and citric acid are employed as an effervescent ingredient. The tablets were made utilizing the direct compression method. The created tablets were tested for thickness, weight variation, hardness, friability, and further, all formulations were put through a 24-hour in-vitro release test using 0.1 N HCL. All of the formulations performed well in pre-formulation investigations. The kind of polymer employed in Keywords: Floating tablet, HPMC K15M, Guar gum, Montelukast sodium, Gum Xanthan. [Download Article] [Download Certifiate] |