Abstract

AMELIORATION OF L-NAME INDUCED LIVER DYSFUNCTION IN MALE WISTAR RATS BY FERMENTED UNRIPE PLANTAIN JUICE

Arhoghro Ejovwoke Marcellinus*, Berezi E. Peter, Madock Obebinaru Joshua, Owotgwun Kasirotu Levi and Agberia Steve Obruche

ABSTRACT

L-NAME (L-NG-nitoarginine methyl ester) is a known nitric oxide synthase inhibitor that has been widely used to induce experimental liver dysfunction in animal models. The present study assessed the potential protective effects of fermented unripe plantain juice (FUPJ), against L-NAME induced liver dysfunction in Male Wistar Rats. Twenty (20) healthy Wistar rats weighing within 110-200g were randomly divided into four groups: Control, L-NAME, FUPJ only, L-NAME + FUPJ, FUPJ treatment only. L-NAME was administered orally to the respective groups for 2 weeks, while FUPJ was given concurrently. Result showed that the potential of FUPJ on L-Name-induced Liver dysfunction in serum ALT and ALP created a significant (p<0.05) rise in ALT (138.71 ± 2.61) and ALP (146.17 ± 1.29) compared to the normal control group. In comparison to the control group, serum ALT (82.28 ± 5.24) and ALP (86.18 ± 2.66) levels rose after treatment with 200 mg/kg body weight of fermented unripe plantain juice. Also the results demonstrated a statistically significant (p<0.05) decrease in serum SOD (3.22±0.32), GSH (3.04 ± 0.09) and CAT (2.55 ± 0.06) respectively. MDA levels in the L-Name treated group were noticeably higher than in the regular control group (2.12± 0.13). Following post-treatment with 200 mg/kg body weight of FUPJ extract, levels of SOD (4.96 ± 0.18), CAT (4.89± 0.21), and GSH (5.78 ± 0.18) significantly decreased in comparison to the control group. Conclusively the study showed that fermented unripe plantain juice (FUPJ)have ameliorative potential against L-Name induced liver toxicity.

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