Abstract

IN VIVO AND IN VITRO APPROACHES TO ANTI-DIABETIC DRUG SCREENING: AN EXHAUSTIVE REVIEW

Prasanna Dalvi*, Prof. Dr. Pandurang Gaikwad, Prof. Hemant Pagar

ABSTRACT

Diabetes mellitus is a prevalent medical condition with the potential for serious complications. It is a major concern worldwide, and inducing the condition in animal models is necessary for advancing our knowledge of its pathogenesis. This understanding can lead to the development of new therapies and, ultimately, a cure for diabetes. Approximately 90% of diabetes patients worldwide have Type 2 diabetes. There are various methods available for screening new antidiabetic drugs, including in-vivo and in-vitro techniques. In-vivo models typically use chemicals such as streptozotocin and alloxan to induce diabetes, whereas in-vitro techniques show the direct effect of drugs on the cells responsible for diabetes in humans. In-vitro techniques provide more accurate data and possible mechanisms involved in the development of diabetes. Newer techniques, such as inducing diabetes with the help of viruses, have also been introduced and are proving to be a useful tool in evaluating antidiabetic drugs. This review provides a vast resource about diabetic models in one place and could be a valuable tool for researchers studying diabetes.

Keywords: Diabetes, Streptozotocin, Alloxan, in vivo techniques, in vitro techniques, diabetes screening methods.