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All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
RECENT ADVANCEMENT ON ORAL BIOLOGICS
Prayag Raval*, Seshadri Nalla and Arpan Chudasama
ABSTRACT
Patients typically opt for oral administration of medications because of its convenience. Biologics cannot be administered orally at this time. The gastrointestinal tract carries out multiple functions in the body, posing difficulties for the absorption of intricate macromolecules consumed. Biologics are very vulnerable to the severe circumstances of the digestive system and encounter substantial obstacles when trying to pass through the intestinal mucosa. Biologics show great potential in treating metabolic diseases, aging, and inflammatory conditions. Oral administration of these drugs is widely acknowledged as a critical goal for chronic conditions. After years of thorough investigation, administering biologics orally is now showing its feasibility. There has been substantial debate over the difficulties linked to the management Keywords: Oral delivery, biologics, absorption enhancers, gastrointestinal barriers, intestine, receptor-mediated uptake, paracellular transport, transcellular transport. [Download Article] [Download Certifiate] |