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DOES STAT3 KNOCKDOWN AFFECT HCV REPLICATION
*Shaymaa M. M. Yahya, PhD
ABSTRACT
Hepatitis C virus (HCV) is considered as a major health problem, affecting more than 170 million individuals worldwide. Host genes were found to modulate viral infection. Studies from animal models have shown that STAT3 plays an important role in cell proliferation, survival, and transformation in the liver. STAT proteins play an important role in the regulation of inflammatory responses by Antigen presenting cells (APCs). This study aimed to evaluate the effect of STAT 3 silencing on HCV replication. Con1 cells were transfected with 5nM siSTAT3 using high perfect transfection reagent. STAT3 Keywords: . [Download Article] [Download Certifiate] |