Abstract

CHEMISTRY, BIOLOGICAL PROPERTIES AND TOXICITY OF 1,4-DIOXANE: A REVIEW

Poonam Yadav*, Prashant Kumar and Prashant Kumar Katiyar

ABSTRACT

1,4-Dioxane was first identified in 1863 and became available for commercial use in the 1930s as a solvent in cellulose acetate and plastics manufacturing. The present review was based on the chemistry and biological properties of 1,4-dioxane. The 1,4-Dioxane is a heterocyclic organic compound, classified as an ether. It is a colourless liquid with a faint sweet odor similar to that of diethyl ether. The compound is often called simply dioxane because the other dioxane isomers (1,2- and 1,3-) are rarely encountered. 1,4-Dioxane is absorbed rapidly and completely following oral and inhalation exposure, with much less absorption occurring from the dermal route. In both rats and humans, 1,4-dioxane is primarily metabolized to b-hydroxyethoxyacetic acid (HEAA), which is excreted in the urine. It showed the involvement of NMDA receptor in breast cancer. It concluded that 1,4-dioxane and its derivatives are effectively used as anti-tumour, Hematologic malignancies, anticancer, antimalarial, antimicrobial, and antiviral agent. It might be a promising moiety for the treatment various cancer subtypes specially breast and prostate gland cancer.

Keywords: 1,4-Dioxane, Chemistry, Biological properties, Anticancer, Toxicity.