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EVALUATION OF ANTI-ULCER ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACTS OF WHOLE PLANT OF BYTTNERIA HERBACEAE IN RATS
Bharathi K. N.* and Ankitha M.
ABSTRACT
The present study was carried out to evaluate the anti-ulcerogenic activity of aqueous and ethanolic extracts of whole plant of Bytteneria herbaceae against pylorus ligation model and ethanol-induced gastric mucosal damage in rats. Single dose of 200mg and 400mg/kg.b.w.p.o. of extracts were used in the study. The antiulcer activity was assessed by determining volume of gastric content, pH, total acidity, ulcer score, ulcer index and percentage protection in pylorus ligation model. Omeprazole (30 mg/kg) was used as standard drug. In the ethanol induced mucosal damage ulcer score, ulcer index and percentage protection was determined, sucralfate (100 mg/kg.b.w.p.o. was used as standard. Both aqueous and ethanolic extracts of whole plant of Byteneria herbaceae exhibited antiulcer activity as there was significant (p<0.001) reduction in ulcer score induced by pylorus Keywords: Peptic ulcer, pylorus ligation, ethanol, Bytteneria herbaceae [Download Article] [Download Certifiate] |