Abstract

POTENTIAL INTERACTIONS OF ANTICOAGULANT WITH OTHER DRUGS IN ISCHEMIC STROKE PATIENTS

Eka Fitrianda*, Dian Restasari and Lola Azyenela

ABSTRACT

Ischemic stroke is one of the cardiovascular diseases that can cause death. Usually the treatment of ischemic stroke uses more than one drug therapy, so it has the potential to facilitate drug interactions. For this reason, the purpose of this study is to determine the potential for anticoagulant drug to interact with other drugs in the therapy of ischemic stroke patients in the neurology inpatient installation at M. Djamil Hospital in Padang in 2020-2021. This study is a descriptive observational study with retrospective data collection using purposive sampling technique. The research instrument used was medical record data for ischemic stroke patients. Potential drug interactions were identified using online databases, namely Drugs.com and Medscape. The study was conducted on 31 patients who were included in theinclusion criteria. From these 31 patients, 106 potential drug interactions were obtained, consisting of 20 potential interactions classified as major severity (19%), 75 potential interactions with moderate severity (73%), and 8 potential interactions with minor severity (8%). Based on the mechanism of interaction, there were 79 (77%) potential drug interactions in the pharmacokinetic phase and 24 (23%) potential pharmacodynamic interactions. The interaction of anticoagulant drugs with other drugs in ischemic stroke patients hospitalized at M Djamil Padang Hospital with the highest potential is the interaction of warfarin with acetaminophen, which is the potential for increased bleeding risk. From the results of this study, it can be concluded that there are a number of potential interactions of anticoagulant groups with other drugs in ischemic stroke patients treated at M. Djamil Padang Hospital in 2020-2021.This potential interaction data can be useed to formulate monitoring and management plans for patients who receive the same combination of drugs in the future.

Keywords: Drug interactions, Anticoagulants, Ischemic stroke.