Abstract

DESIGN, SYNTHESIS AND EVALUATION OF ANTI-INFLAMMATORY ACTIVITY OF SCHIFF BASE CONTAINING 2,4-DISUBSTITUTED THIAZOLE RING

Mangal Kamble* and Dr. Shubhangi Daswadkar

ABSTRACT

A series of 2-(arylidene)-1-(3-nitrophenyl) thiazol-2-yl) hydrazine(2a-j) were synthesized by the Reaction of Schiff Base Thiosemicarbazone with substituted phenacyl bromide few drop of glacial acetic acid. The structures of synthesized compounds were established by chemical analysis (FT-IR, 1H-NMR, 13C-NMR, Mass). The synthesized compounds 2b, 2h, and 2i were screened for Anti-inflammatory Activity by the carrageenan-induced paw edema method. The synthesized compounds showed significant anti-inflammatory activity against target macromolecule Cyclooxygenase when compared with standard celecoxib. As a result, these substances can be seen as prospective lead compounds for the creation of fresh anti-inflammatory medications with novel mechanisms of action.

Keywords: Schiff Base, 2,4-Disubstituted thiazoles, Anti-inflammatory, Thiosemicarbazone.