Abstract

FORMULATION AND EVALUATION OF TAMARINDUS INDICA SEED USED AS PHARMA EXCIPIENT

Mrinal Sikdar*, Abhijit Gothoskar, Manoj Sarangi, Sandeep Waghulde, Babita Kumari, Ajit Patil

ABSTRACT

Generally synthetic polymers were used to formulate any pharmaceutical dosage form. But biodegradability was problematic for any synthetic polymer. For that reason natural polymer were used. Tamarind seed polymer (TSP) was extracted from seed of Tamarindus indica, which have numerous pharmaceutical excipient properties. In the current study, matrix Ofloxacin bioadhesive sustained release tablet were prepared by two technique (Wet granulation and Direct Compression) containing different concentration of TSP and saw its binding as well as bioadhesive property. The tablets were evaluated for different QC test, content uniformity, swelling index, invitro dissolution test, bioadhesive strength test and also comparison study between the two techniques. Finally it was determined that wet granulation show a linear drug release pattern than direct compression and also it was concluded that TSP has good binding as well as bioadhesive properties in both techniques and it will used as Pharmaceutical excipients.

Keywords: Tamarind seed, Ofloxacin, Bioadhesive tablets, Bioadhesive strength