Abstract

A RESEARCH ARTICLE ON FORMULATION AND EVALUATION OF FLOATING BEADS OF PANTOPRAZOLE SODIUM FOR PEPTIC ULCER DISEASE

Ankuj Pandey*, Anubhav Anand, Shivam Jaiswal and Aman Kumar Singh 

ABSTRACT

Proton pump inhibitor medications like Pantoprazole sodium are used to treat gastro esophageal reflux disease and peptic ulcers. In this study, sodium alginate, Xanthan gum, and chitosan were used to create Pantoprazole sodium beads by ionotropic gelation procedures. To vary compactness, seven formulations with a sodium alginate core were coated with chitosan-Xanthan gum in various concentrations. A solution of chitosan and xanthan gum was combined at various C/X ratios. The size of the beads, the effectiveness of the entrapment, the swelling index, the in-vitro drug release, and the in-vivo ulcer caused by ethanol were all assessed for all the formulations. For formulations F6 and F2, the percentages of drug entrapment efficiency were 89.45±2.03 and 61.45±2.43 percent, respectively. For formulation F3, the highest swelling was determined to be 88.7 percent, while for formulation F6, the minimum swelling was found to be 64.06 percent. Formulation F3 displayed the longest possible floating time (35 percent of beads up to 30 hours). Animals administered with the standard and test formulation significantly reduced their ulcer index in in vivo tests using a rat model of ethanol-induced ulcer. The effective particular drug can be improve with a well-designed floating drugs delivery systems by addressing some of the drawbacks of conventional therapy.

Keywords: Gastroretentive drug delivery, Core-shell particles, Floating beads, Sodium alginate. Chitosan, Xanthan gum.