Abstract

AN OVERVIEW OF NANOSTRUCTURED LIPID CARRIERS (NLC)

Rohit Sonawane*, Kajal Wakchaure, Priya Kotkar

ABSTRACT

The body can receive drugs by a variety of pathways, but most of these have drawbacks such as poor solubility, absorption, first-pass metabolism, and poor bioavailability. For this reason, nanostructured drug delivery systems were developed. Drug delivery devices known as nanostructured lipid carriers (NLC) use a core matrix made up of both liquid and solid lipids. This method helps us not only in overcoming those issues but also in lowering the dosage, minimising systemic side effects, and administering the medication to the intended site of action. These nanotechnology-based delivery systems can be utilised to administer a range of medications via oral, topical, transdermal, ophthalmic, nasal, and parenteral routes. In the early 1990s, solid lipid nanoparticles (SLN) were developed as an alternative carrier system to polymeric nanoparticles, liposomes, and emulsions. The study explores the benefits and possible drawbacks of using SLN in topical medication compositions. The nanostructured lipid carriers (NLC) are a novel class of lipid nanoparticles with solid matrix. The structural specialities of NLC are described, and various improvements are discussed. Some of these include increased loading capacity, long-term stability in both physical and chemical aspects, triggered release, and the potential for supersaturated topical formulations. The technologies for creating the final topical formulation for NLC are explained, with a focus on creating highly concentrated lipid nanoparticle dispersions. Lipid content: 30–80%. NLCs have the ability to modify the pharmacokinetic properties of drug carriers to improve therapeutic effect, increase drug distribution to the target organ, and reduce adverse Side effects. The preparation methods and application of NLC are thoroughly explained in this paper.

Keywords: 1990s, solid lipid nanoparticles (SLN) were developed as an alternative carrier system to polymeric nanoparticles, liposomes, and emulsions. The study explores the benefits and possible drawbacks of using SLN in topical medication compositions. The nanost