Abstract

DEVELOPMENT AND CHARACTERIZATION OF KETOROLAC TROMETHAMINE ENCAPSULATED TRANSETHOSOMES FOR ENHANCED TRANSDERMAL DELIVERY

Jessy Shaji*, Sharvari Garude

ABSTRACT

Objective: The aim of this current research is to study a novel carrier, transethosome, for its enhanced transdermal delivery of ketorolac tromethamine (KT). Methods: Transethosomes (TELs) are elastic vesicles composed of phospholipid, ethanol and edge activator (surfactant). TELs were prepared by cold method and characterized by particle size, entrapment efficiency, transmission electron microscopy (TEM), ex-vivo skin corrosive test, in-vitro dissolution, ex-vivo permeation studies and in-vivo study. Results: Microscopic examination of transethosomes showed soft, malleable and spherical vesicles with a smooth surface. Vesicle size and % EE of the optimized transethosomal formulation was found to be 180 ± 70 nm and 80.08 ± 4.5% respectively. Zeta potential of the optimized transethosomal formulation was found to be -46.19± 13.3 mv. The ex-vivo study showed transdermal flux of transethosomal gel (47.43± 0.2 μg/cm2/h) 3fold higher than that obtained after application of plain drug gel (15.05±0.09 μg/cm2/h), and 2.7fold higher than that of the hydroethanolic solution of drug (17.33± 0.15μg/cm2/h). Conclusions: Data obtained from this experimental work concludes that transethosomal formulation is safe, very effective and promising drug carrier for transdermal delivery of drug.

Keywords: ketorolac tromethamine, transdermal delivery, transethosomes, permeation studies, in- vivo study.