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BUCHHOLZIA CORIACEA (WONDERFUL KOLA) SEED EXTRACT EFFECTS ON SOME CARDIOPROTECTIVE, PANCREATIC AND LIPID PROFILE VALUES IN ALLOXAN INDUCED WISTAR RATS
*Karibo Amakiri Okari and H. O. Asuzu-Samuel
ABSTRACT
Diabetes a chronic condition that is characterized by elevated blood glucose level and various heart related diseases. The Buchholzia coriacea (Wonderful Kola) seed extract effect on cardiac tissue, pancreas and lipid-profile parameters in alloxan induced Wistar rats was evaluated. Mature fruits of Wonderful Kola were gathered and authenticated. The seeds were processed, dried, and extracted into a methanolic extract. Twenty-five albino rats were obtained, acclimatized, and randomly divided into five groups; The normal control group was fed with water and feed only, positive control group was induced diabetes with alloxan and was not treated throughout the study, the known standard drug group was induced and treated with metformin daily, while the test group was divided into low dose test group and high dose test group. The low dose test group was administered with 250mg/kg of Buchholzia coriacea(Wonderful Kola) and the high dose test group was treated with a high dose of Keywords: Alloxan, Cardioprotective, Pancreatic, Lipid and Buchholzia Coriacea. [Download Article] [Download Certifiate] |