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FORMULATION AND EVALUATION OF DOMPERIDONE ORODISPERSIBLE TABLETS
Mahmoud Mahyoob Alburyhi*, Maged Alwan Noman, Abdalwali Ahmed Saif, Yahya Abduh Salim Mohamed and Jalal H. Abdullah
ABSTRACT
The most common and preferable route of drug administration is through the oral route. Novel oral drug delivery systems aim to enhance safety and efficacy of drug molecule by formulating a convenient dosage form for ease of administration and to achieve better patient compliance. Orodispersible tablets (ODTs) are among these systems, the concept of Orodispersible tablets is to disperse the tablets within seconds in the mouth in the presence of saliva with no need for water, and without any difficulty of swallowing due to the presence of superdisintegrants in their formulation. This study aims to solution the common problem of dysphagia by developing Orodispersible tablets that rapidly dissolve in the oral cavity without the need for water. The objective is to provide a convenient dosage form that improves patient compliance and enhances the safety and efficacy of therapy. Ten different formulations have been developed in this study physical and chemical tests, dissolution testing indicated good performance in certain formulations, the formulation was optimized to achieve desired characteristics such as optimum Keywords: Domperidone, Orodispersible tablets, Superdisintegrant, Formulation. [Download Article] [Download Certifiate] |