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FORMULATION AND EVALUATION OF RIVAROXABAN NANO SUSPENSION BY SOLVENT METHOD
T. Sandeep*, V. Hymavathi, S. A. Mastan, Srinivas Nammi and Eswar Ganesh
ABSTRACT
Objective: The present work was designed to study the formulation and evaluation of the Rivaroxaban nano suspension by solvent evaporation method. Methods: Rivaroxaban nanosuspension was prepared by the solvent evaporation method. For this purpose, Rivaroxaban was dissolved in acetone at room temperature (organic phase). This was poured into water containing different stabilizers of PVP K30, PVA, POLAXOMER, and SLS maintained at room temperature and subsequently stirred on a magnetic stirrer which is stirred at rpm 800-1000 for 30 min to allow the volatile solvent to evaporate. Organic solvents were left to evaporate off under a slow magnetic stirring of the nanosuspension at room temperature for 1 hour followed by sonication for 1 hour. Results: In the present study, oral nanosuspension of Rivaroxaban was prepared. All the prepared formulations were found to be having drug content within acceptable Keywords: Formulation, Nano-suspensions, Rivaroxaban, Solvent Method. [Download Article] [Download Certifiate] |