Abstract

FORMULATION AND EVALUATION OF RIVAROXABAN NANO SUSPENSION BY SOLVENT METHOD

T. Sandeep*, V. Hymavathi, S. A. Mastan, Srinivas Nammi and Eswar Ganesh
Babu T.

ABSTRACT

Objective: The present work was designed to study the formulation and evaluation of the Rivaroxaban nano suspension by solvent evaporation method. Methods: Rivaroxaban nanosuspension was prepared by the solvent evaporation method. For this purpose, Rivaroxaban was dissolved in acetone at room temperature (organic phase). This was poured into water containing different stabilizers of PVP K30, PVA, POLAXOMER, and SLS maintained at room temperature and subsequently stirred on a magnetic stirrer which is stirred at rpm 800-1000 for 30 min to allow the volatile solvent to evaporate. Organic solvents were left to evaporate off under a slow magnetic stirring of the nanosuspension at room temperature for 1 hour followed by sonication for 1 hour. Results: In the present study, oral nanosuspension of Rivaroxaban was prepared. All the prepared formulations were found to be having drug content within acceptablelimits in the range of 79.16 to 97.16%, respectively. All the prepared formulations were found to be having entrapment efficiency within acceptable limits in the range of 82.15%-97.31%, respectively. As the polymer concentration increases, the drug release rate decreases, whereas nanosuspension strength increases. Optimized formulations of nanosuspension displayed zero order release kinetics and drug release. IR spectroscopic studies indicated that there are no drug-excipient interactions. Conclusion: When compared to other all the formulations F9 is the best formulation which showed 99.84% of drugs released respectively within 25 min and follows Zero order release kinetics.

Keywords: Formulation, Nano-suspensions, Rivaroxaban, Solvent Method.