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VINCA ALKALOIDS CATHARANTHUS ROSEUS A HERBAL MEDICINE
Anjan Biswas*, Mrs. Deepika Deopa, Dr. Vijay Singh
ABSTRACT
Vinca alkaloid (derived from Catharanthus roseus) are a subset of drugs (anti-mitotic and anti-microtubule alkaloid) obtained from the Madagascar periwinkle plant. They are naturally extracted from the pink periwinkle plant, Catharanthus roseus G. Don and have hypoglycemic as well as cytotoxic effects. They block beta-tubulin polymerization in a dividing cell. The plant is native of Madagascar and is found in many tropical and subtropical countries especially in India, Australia, South Africa and North and South America. The plant is cultivated as garden plant in Europe and India. The vinca alkaloids are also important for being cancer fighters. The Madagascar periwinkle has a reputation in folk remedy in the treatment of diabetes. vinka alkaloid are used as immunosuppressive drugs. Vinca Alkaloid are chemically indole alkaloids and are known to possess anti-cancer, anti-hypertensive and anti- diabetic roles. The principle members of group are vincristine, vinblastine, vindesine, vinorelbine. Vinflunine is Keywords: Vinka alkaloid, madagascar periwinkle,anti-microtubule, vincristine, vinblastine, vindesine, vinorelbin. [Download Article] [Download Certifiate] |