Abstract

ROLE OF TOLL LIKE RECEPTOR IN PAN – CANCER

Sagar Ashwini Hanmant*, Dr. Vanita Baburao Wadewale and Kapse V. N.

ABSTRACT

Toll-like receptors (TLRs) are important molecules expressed by innate immunity cells that allow them to identify pathogen-associated chemical patterns and recognise pathogens in order to develop immune responses. TLRs have been shown to promote the carcinogenesis through proinflammatory, antiapoptotic, proliferative, and profibrogenic signals within the tumor microenvironment or tumor cells themselves; while on the other hand, TLR signaling induces a highly sensitive and effective tumor immunosurveillance by activating specific immune cells like dendritic cells (DCs), natural killer cells (NKs), and cytotoxic T lymphocytes (CTLs), all of which have antitumorigenic activity. These results also highlight the need for the creation of vaccines that employ TLR ligands to trigger immunological responses and designate malignant cells as particular targets for
immune system-mediated destruction. In this review, we will focus on the role of Toll Like Receptors in cancer: role of TLR natural and synthetic modulators

Keywords: Toll Like Receptor, Lymphocytes, Carcinogens, Dendritic cell, Natuaral killer cell.