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REVIEW ON NAVIGATING THE ENIGMA: UNRAVELLING CHALLENGES IN EARLY DISCRIMINATORY DIAGNOSIS AND PREDICTING COGNITIVE DECLINE IN DEMENTIA WITH LEWY BODIES
Ezilkkavia S.*, Felic S., Dr. Raghul G. and Senthil M.
ABSTRACT
Background: Early and precise diagnosis of Dementia with Lewy Bodies (DLB) poses challenges due to the low sensitivity of clinical criteria and a lack of universally accepted biomarkers, complicating differentiation from Alzheimer's disease (AD). Despite being the second most prevalent form of neurodegenerative dementia, DLB is often under-recognized, impacting its prognosis. Methods: This comprehensive review focused on identifying biomarkers for DLB through a systematic literature search covering EEG, imaging, genetics, and CSF markers. Key findings highlighted scintigraphy of the striatal dopamine transporter system using FP-CIT SPECT, along with promising outcomes in cardiovascular autonomic function studies and innovative CSF techniques. Structural MRI, perfusion SPECT, genetics, and EEG studies illuminated group-level differences between DLB and AD. Results: Despite challenges, potential biomarkers, Keywords: . [Download Article] [Download Certifiate] |