Abstract

BRIEF REVIEW ON PHYSIOCHEMICAL PROPERTIES OF CHALCONE, SYNTHETIC PATHWAY AND ANALOGOUS WITH APPLICATION

Ganesh Shingare, Sureshkumar K. Dhakhda* Dharnidhar Mundhe, Balaji Madje, Jaishree Chamargore

ABSTRACT

Chalcones are group of plant derived bioactive polyphenolic compounds belonging to flavonoids family. Human being had been using natural chalcones as traditional herbal medicine from many centuries. Chalcone, a colored organic compound contains three carbons α, β-unsaturated carbonyl system linked to two aryl rings. Trans form is thermally more stable than cis form. The various pharmacological activities include antioxidant, antifungal, antihypertensive, antiviral, anticancer, anti-protozoal, anti-HIV, antibacterial, antimalarial, antifungal, anticonvulsant. Chalcone had an object of interest for both academic and industry. The industrial application includes liquid crystals, fluorescent chemicals, metal sensors, corrosion inhibitor and plant hormones. This article briefly reviewed chalcone and their analogous reported for differentapplications and synthetic methods.

Keywords: Chalcone, flavonoids, ?, ?-unsaturated, anticancer, physiochemical, analogous.