Abstract

EVALUATION OF ANTI DEPRESSANT ACTIVITY OF CALOTROPIS GIGANTEA BY USING EXPERIMENTAL RATS

S. R. Rahul*, Y. Anil Kumar, K. Anand, B. Gayathri and B. Thangabalan

ABSTRACT

Anti-Depressant activity of Calotropis Gigantea was evaluated in Experimental rats. The present study aqueous extract of Calotropis Gigantea leafs has shown promising results in experimental depression. These studies are valuable for identifying lead compounds for anti-depressant drugs, keeping in mind the side effects of presently used antidepressants. The standardization of the extracts, identification and isolation of active principles along with pharmacological studies of these principles may be considered for further detail studies. Still further human studies are needed to prove the safety and efficacy of long term administration of aqueous extract of Calotropis Gigantea leafs. In the light of observations made it may be envisaged that Calotropis Gigantea (CG) leafs extract can be used as a potential adjuvant in the treatment of depressive disorders. The extract of Calotropis Gigantea leafs of showed the results were increased that the
standard imipramine it indicates the test extract poses antidepressant activity. The investigations of aqueous extract of Calotropis Gigantea leafs (100mg/kg and 200mg/kg) in both Forced Swim Test (FST) & Tail Suspension Test (TST) models in rats were showed invivo antidepressant activity. In this study the results were obtained increased such as imipramine. So it is concluded that the aqueous extract of Calotropis Gigantea leafs should possessed the antidepressant activity.

Keywords: Anti-Depressant activity, Calotropis Gigantea (CG), Forced Swim Test (FST) & Tail Suspension Test (TST).