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STABILITY INDICATING HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS DETERMINATION OF LAFUTIDINE & DOMPERIDONE IN ITS DOSAGE FORMS
Prashant D. Ghode*, Dr. Sunil P. Pawar
ABSTRACT
A simple, rapid, precise, sensitive and reproducible stability indicating Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for determination of Lafutidine and Domperidone in capsule dosage form was developed. Chromatographic separation was achieved on Zodiac C18 (250mm × 4.6 mm, 5μm) column maintained at ambient temperature eluted with mobile phase at flow rate of 1 ml/min. The mobile phase consists of o-Phosphoric Acid and Acetonitrile in the ratio 65:35% v/v was used and the determination was carried out at 215nm. The retention time for Lafutidine and Domperidone were 4.901 min and 8.274 min respectively. The linearity was found to be in Keywords: Lafutidine, Domperidone, Estimation, HPLC, Stability Indicating. [Download Article] [Download Certifiate] |