Abstract

REVIEW ON SPHERICAL CRYSTALLIZATION: PARTICLE DESIGN TECHNIQUE

Dipti D. Patil*, Sonal A. Satpute and Priyanka S. Mali

ABSTRACT

Spherical agglomeration is a modernized technique where the drug crystals are converted to spherical form to improve compressibility, flowability and packability for the development of directly compressible pharmaceutical dosage forms. It also save money and time for tableting. The spherical crystallization further developed to enhance dissolution rate characteristics of poorly water soluble drugs by using hydrophilic polymers. The principle steps involved in the process of spherical crystallization are flocculation zone, zero growth zone, fast growth zone and constant size zone The spherical crystallisation was further developed for use with hydrophilic polymers to improve the features of weakly water soluble medications' rate of dissolution. It can also be used to maintain the release of drugs from solid dosage forms. The present review aims at the detailed comprehensive study about the technique, advantages and disadvantages, mechanism, solvent change method of manufacturing of spherical agglomerates and characterization of spherical agglomerates.

Keywords: Spherical crystallization, Spherical agglomeration, Direct compression, Flowability, Compressibility.