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DEVELOPMENT AND EVALUATION OF FLOATING MICROSPHERES OF CEFIXIME FOR ORAL CONTROLLED RELEASE
K. M. Lokamatha Swamy* and Ameer Pasha
ABSTRACT
The current study was aimed to improve the oral bioavailability of cefixime, an orally active antibiotic used to manage various infections, by developing floating microspheres. Cefixime is known to have poor bioavailability due to its slow and incomplete absorption from the gastrointestinal tract (GIT). To address this issue, sodium alginate (SA) as a coating material and combined it with xanthan gum (XG) and guar gum (GG) were emplyoed to enhance gastric residence time. Initially, cefixime microspheres were prepared using SA alone as the coating material. Subsequently, floating microspheres were formulated with a coat comprising SA in combination with XG and GG. Developed floating microspheres were evaluated for percentage yield, drug content, microencapsulation efficiency, swelling index, particle size analysis, floating ability, and in vitro dissolution studies. Fourier- Keywords: Floating microspheres, cefixime, bioavailability, sodium alginate, xanthan gum, gaur gum. [Download Article] [Download Certifiate] |