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A NOVEL ULTRAVIOLET-VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF CARBAMAZEPINE IN BULK DRUG AND ITS FORMULATION
P. Pravalika* and L. Madhuri
ABSTRACT
For the quantitative determination of carbamazepine in a pharmaceutical formulation, a new straightforward, accurate, quick, precise, reproducible, and cost-effective spectrophotometric approach has been developed and validated in accordance with the ICHQ2 (R1) guidelines. The highest absorption wavelength of carbamazepine solution was measured over the UV-Visible spectrum. The absorbance was measured at the wavelength of maximum absorbance using several calibration standards of carbamazepine. Calculations were made to determine the linearity and range of the calibration curve of concentration vs. absorbance. QC standards were validated, including accuracy, precision, LOD, LOQ, and robustness. It was found that the maximum wavelength of carbamazepine was 285 nm with 0.1N NaOH Keywords: UV-Visible spectrometry, Carbamazepine, Validation, Linearity, Anti seizures. [Download Article] [Download Certifiate] |