Abstract

REVIEW ARTICLE, SICKLE CELL DISEASE: NEW OPPORTUNITIES AND CHALLENGES IN NORTH MAHARASHTRA

*Nikhil Lohar, Rupesh More, Mayur Patil, Tushar Mohare, Vishal Avhad, Hitesh Patil and Kalpesh Wagh

ABSTRACT

Sickle cell disease is one of the most common genetic causes of illness and death in the world. This is a review of SCD in North maharashtra which bears the highest burden of disease. The first section provides an introduction to the molecular basis of sickle cell disease and the pathophysiological mechanism of selected clinical events. The second section discusses the epidemiology of the disease (prevalence, morbidity, and mortality), at global level and within north Maharashtra. The third section discusses the laboratory diagnosis and management of sickle cell disease, emphasizing strategies that been have proven to be effective in areas with limited resources. Throughout the review, specific activities that require evidence to guide healthcare in north Maharashtra as well as strategic areas for further research, willbe highlighted.

Keywords: This is a review of SCD in North maharashtra which bears the highest burden of disease.