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FORMULATION AND EVALUATION OF EXTENDED RELEASETABLETS i.e., FILM COATED TABLETS OF DESVENLAFAXINE SUCCINATE EXTENDED RELEASE TABLETS
Mani Kanta Reddy* and Prof. A. Pramela Rani (M.Pharm, Ph.D)
ABSTRACT
The main objective of work was to develop pharmaceutically elegant and stable enteric coated tablet formulation for highly unstable drug in acidic environment using pH dependent polymer. Development of Enteric coated tablets were done for Extended Release of drug. Coating was done by using Opadry II pink 85F570240 - CN. Characterization of Drug and Excipients was carried out including compatibility studies of drug and excipients. Desvenlafaxine succinate was formulated using carrier Hypromellose 2208 (Methocel K 100M Premium CR), Microcrystalline cellulose (Microcel 101 SD) & Colloidal silicon dioxide (cab-o-sil, grade M5). Evaluation was carried out using suitable parameters like solubility, percentage yield, drug content, in-vitro drug release, FTIR and SEM. Further granules were formulated from the optimized batch of formulated SDs. Pre-compression studies of granules were carried out like Tapped density, Bulk density, Angle of repose, etc. of Granules. Four Keywords: Film coated, Desvenlafaxine, Stability studies, Shifting. [Download Article] [Download Certifiate] |