![]() |
|||||||||||||
|
All | Since 2019 | |
Citation | 5450 | 3969 |
h-index | 23 | 20 |
i10-index | 134 | 84 |
LONG-TERM EFFECTIVENESS AND SAFETY OF ENDOXIFEN IN THE TREATMENT OF ACUTE BIPOLAR MANIA: A CASE REPORT
Abhishek Chakladar, Nand Kumar*, Rohit Verma and Manmeet Kaur Brar
ABSTRACT
Antipsychotic drugs and mood stabilizers as mono or combination therapy are first-line agents in the treatment of the manic phase of bipolar I disorder. Endoxifen a potent inhibitor of the protein kinase C (PKC) signaling pathway, is efficacious in the control of acute bipolar mania, at doses of 8 mg, for a period of 3-weeks. However, there is a dearth of data about the long-term use of endoxifen. Here we describe a case of acute bipolar mania not able to tolerate clozapine therapy, efficaciously controlled with long-term use (9-weeks) of endoxifen8 mg, without any adverse effects, along with complete remission of manic symptoms. Keywords: Endoxifen, Acute bipolar mania, Long-term use, safety, Effectiveness. [Download Article] [Download Certifiate] |