Abstract

DESIGN AND SYNTHESIS OF SOME NOVEL PYRAZOLE DERIVATIVES OF BENZOXAZOL WITH ANTIMICROBIAL AND ANTI-INFLAMMATORY ACTIVITY

B. Srinivas, G. Brahmeshwari*

ABSTRACT

A series of novel 2-dialkylamino-N-[5-(4-formyl-3-phenyl-pyrazole-1-carbonyl)-benzooxazol-2-yl]-acetamide (6a-i) was synthesized in good yields from four intermediates such as methyl-2-(2-chloroacetamido) benzoxazoole-5-carboxylate (2), 2-(2-dialkyl amino-acetylamino)-benzooxazole-5-carboxylic acid methyl ester (3), 2-dimethylamino-N-(5-(hydrazinocarbonyl-benzooxazole-2-yl)-acetamide (4) and 2-dialkylamino-N-[5-(1-phenyl-ethylidene-hydrazinocarbonyl)-benzooxazole-2-yl]-acetamide (5a-i). The synthetic route leading to the title compounds is commenced from commercially available methyl-2- aminobenzoxazoole-5-carboxylate (1). The chemical structures of the newly synthesized compounds were elucidated by their IR, 1H NMR, mass spectral data and elemental analysis. Further, all the target compounds were screened for their antimicrobial and anti-inflammatory activity.

Keywords: 1H NMR, IR, chloroacetamido