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EFFECT OF FERULIC ACID ON MYOCARDIAL TISSUE LEVELS OF TBARS, GSH, SOD, CATALASE AND TISSUE NITRATE IN RATS
Dr. Mekala Sunil*, Dr. S. Naga Subramanyam, A. Pravallika, Ch. Santhi Swaroopini, M. Pallavi, P. Navya and N. Sravani
ABSTRACT
The present study was designed to evaluate the cardioprotective role of Ferulic acid on the in vivo myocardial ischemic reperfusion injury in rats. Methods: Male Wistar albino rats were divided into six groups (n=6). The group C & C-IR animals were administered saline orally (sham, I-R Control group), animals group FA-BL1& FA-BL2 recevied ferulic acid 20mg/kg and 40mg/kg b.wt respectively upto 30 days orally without inducing I-R injury and animals group. FA-IR1 & FA-IR2 recevied FA 20mg/kg and 40mg/kg respectively upto 30 days. On the 30th day animals of C-IR, FA-IR1 & FA-IR2 groups were underwent 15 minutes of ligation of left anterior descending coronary artery and were thereafter reperfused by 60 minutes. Results: In the C- IR group, myocardial infarct size was observed by the presence of unstained necrotic tissue, a significant decrease in the levels of endogenous anti oxidant enzymes (GSH,CAT,SOD), tissue nitrate (NO), cardiac markers (LDH, CK, AST) and increased the lipid Keywords: . [Download Article] [Download Certifiate] |