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FORMULATION AND EVALUATION OF TOPICAL FLURBIPROFEN GEL USING DIFFERENT GELLING AGENTS
Kokane Vikrant *, Naik Sonali
ABSTRACT
Flurbiprofen is chemically 2-(3- fluoro-4-phenylphenyl) propanoic acid. It is non steroidal anti inflammatory agent used in the treatment of rheumatoid arthritis and osteoarthritis .Oral administration of this drug is associated with severe gastrointestinal side effects like ulceration and gastro intestinal bleeding. The solution of this problem lies in the fact that, topically applied NSAIDs are safer than oral NSAIDs. The objective of the study was to prepare gel of flurbiprofen using different gelling agents : carbopol 940, carbopol 934, hydroxypropylmethylcellulose and lutrol F-127.These preparations were further compared with marketed flurbiprofen gel.The gels were evaluated for physical appearance, pH, spreadability, extrudability, Keywords: Flurbiprofen, lutrol F-127, carbopol, hydroxypropylmethylcellulose, topical gel. [Download Article] [Download Certifiate] |