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STABILITY-INDICATING ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF THIOCOLCHICOSIDE AND ETODOLAC IN TABLET DOSAGE FORM BY RP-HPLC METHOD
Manda Swapna*, Rongali Indu, Soudamini Alekh Charan and P. Uma Devi
ABSTRACT
A simple, sensitive, accurate reverse-phase high-performance liquid chromatographic (RP-HPLC) method for the stability indicating analytical method development for the determination of Etodolac and Thiocolchicoside has been developed and validated. Separation was carried out on agilent HPLC system equipped with XBD plus C18 column (150 × 4.6 mm i.d.) and UV/VIS detector using Acetonitrile: potassium dihydrogen phosphate buffer (70:30, v/v) as the mobile phase, and detection was carried out at 231nm. The linearity was found to be in the range of 10-50 μg/ml and 10-50μg/ml with (r2=0.992, and r2=0.991) for THC and ETD respectively. The sharp peaks obtained were having clear baseline separation with a retention time of 1.733 min for THC and 2.027 min for ETD with resolution 2.05 The forced Keywords: Etodolac, Thiocolchicoside, HPLC, Stability indicating. [Download Article] [Download Certifiate] |