Abstract

INVESTIGATION AND IN-VITRO STUDIES OF THE ANTIUROLITHIATIC ACTIVITY OF “KALANCHOE PINNATA”

S. Ravichandran M., R. Venkatakrishnan*, S. Nikesh, S. Priya, R. Rishikanth, D. Umesh and V. Vanaja

ABSTRACT

The study aimed to explore the details and anti-urolithiatic activities of “Kalanchoepinnata” leaf extract using various in vitro models and analyze its inhibitory effect on in vitro crystallization. The extract was prepared from dry leaves using ethanol extract The results showed that the extract of “Kalanchoe pinnata” had a greater ability to dissolve calcium oxalate, while Cystone standard showed better demineralization of calcium phosphate. This investigation will support in-vitro studies related to scientific documentation and may help understand the molecular mechanism of litholysis and reveal the phytochemicals responsible for dissolving (or) disintegrating renal calculi. In conclusion, the “Kalanchoe pinnata” extract exhibited significant in vitro anti- urolithiatic activity. The leaves of the plant are historically utilized in ethnomedicine. There are many different ways to prepare medicines, but the most efficient, reliable, and secure approach is yet unknown. Four distinct “K. pinnata” leaf extracts weremade for this investigation using the extraction method. The macroscopical, microscopical, physicochemical, and phytochemical features of the extracts were examined. For their phytochemical investigation, all of the extracts produced meaningful findings; nevertheless, extract stood out as the best extract due to its largest component variety. Important information from this study may be used to choose the optimum extract for preparing folklore.

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