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FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF DICLOFENAC SODIUM
Sujatha*, Srinithya N., Subhash K. S., Swetha M., Vandana M., Varun Kumar V. and Veena R. S.
ABSTRACT
The main objective of this work is to formulate diclofenac sodium transdermal patch to overcome problems associated with short half-life and fluctuations in plasma concentration and to avoid first pass metabolism upon oral administration. The patch were prepared using Solvent Casting Method, using Hydroxy Propyl Methyl Cellulose (HPMC), Poly Vinyl Alcohol (PVA), Ethyl cellulose, Poly Vinyl Pyrolidine (PVP) and Guar gum as polymer, Dimethyl sulfoxide (DMSO) as permeation enhancer and Ethanol: distilled water as solvent. The physical evaluation of the prepared patch include organoleptic observation, percentage moisture content, uniformity test, thickness of film, weight uniformity and folding endurance. The drug release was determined using Franz diffusion cells in phosphate buffer (pH 6.8). The result of physiochemical parameters of the transdermal patch were found satisfactory. Formulation F6 and F7 produce best result among all patches with smooth transparent texture and maximum folding endurance. The patch weight, thickness were found Keywords: Diclofenac Sodium, Guar gum, Natural polymer, Transdermal patch, folding endurance and conventional dosage Form. [Download Article] [Download Certifiate] |