Abstract

FORMULATION AND EVALUATION OF STAVUDINE LOADED MATRIX TABLET USING TAMARIND SEED POLYSACCHARIDE

Kaushilya Verma*, Shubha Shrivastava and Anil Sarathe

ABSTRACT

The objective of this study was to develop matrix tablets of Stavudine for sustained release. Natural polymer obtained from tamarind seeds and studied the effect of various formulation factors such as polymer proportion and effect of filler and channeling agent on the in vitro release of the drug. Stavudine Matrix tablets were prepared by wet granulation method with average weight of drug of 200mg, 280mg and 360mg. and after preparing tablets were evaluated for different evaluation parameters. All the granules of formulations showed compliance with pharmacopeial standards. In vitro dissolution study is clear that the amount of drug release is decreased as the concentration of polymer increased, drug release was found to be retarded. But afterfurther study of the formulation shown that the concentration of polymer is fixed and increase the concentration of channeling agent (lactose), increase the release of drug from matrix tablet. The formulation L1 is selected as the optimized formulation by in vitro drug release for 12 hrs with the release of 95.44%. By the stability studies there is no significant difference in the drug content.

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