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NANOTECHNOLOGY-BASED DRUG DELIVERY SYSTEMS FOR THE TREATMENT OF ALZHEIMER’S DISEASE
S. Shaikh and Pritam G. Kande*
ABSTRACT
Currently, Alzheimer's disease (AD) accounts for more than half of all dementia cases. Although genetics, age, and environmental factors affect the disease, the cause of AD is not yet fully known. Various drugs have been proposed for the prevention and treatment of AD, but the delivery of these therapeutic agents to the brain is difficult. The blood–brain barrier prevents systemic drugs from accessing the central nervous system and designing a suitable system to overcome this barrier has attracted much attention. The intranasal pathway, given its proximity to the brain, provides a great opportunity for drug delivery. Understanding the physiological characteristics of the nose can be useful in selecting the appropriate carrier and material. Some of the emerging vehicles used for nose-to-brain delivery of anti-AD drugs are natural (Such as chitosan) and polymeric (Such as poly (lactic-co-glycolic acid) and polyethylene glycol) nanoparticles (NPs). This Keywords: Alzheimer‘s disease, Polymeric nanoparticles, Solid lipid nanocarriers, microemulsions, Liquid crystals, Targeted delivery, Nose-to-brain. [Download Article] [Download Certifiate] |